Unfortunately there has not been significant innovation to provide effective technologies for sealing tissues, especially internal tissues that are wet. While sutures and staples have been used for decades, they exhibit considerable limitations (they can induce significant tissue damage and their placement is often slow and challenging during minimally invasive procedures). Additionally, there has been minimal innovation to provide adhesive technologies to the pediatric population. Indeed, most technologies designed for adults are sub-optimally used “as is” in children, yet solutions to pediatric problems often require unique design criteria. This talk will explore multiple Next-Gen bio-inspired adhesive technologies to address several unmet medical needs. Through inspiration from the gecko, nano- and micro-topography has been harnessed to achieve biocompatible and controlled tissue adhesion. Towards development of a tissue adhesive glue to seal septal defects in children, we have harnessed inspiration from insect footpads, slugs and sandcastle worm viscous secretions that can create stable underwater adhesive bonds. We have also been inspired by the spiny-headed worm to develop an array of microneedles with biomimetic swellable tips that can achieve strong bonds to tissue through a mechanically interlocking mechanism and can be used to securely affix skin grafts to prevent seromas. This design provides universal soft tissue adhesion with minimal damage and reduced risk of infection compared to staples, and provides opportunity for delivery of bioactive therapeutics. Furthermore, a next-gen adhesive bandage that both securely affixes devices to sensitive neonatal skin and produces minimal dermal stress during rapid removal will be described.