Pediatric medicine has a proud history of innovation. From the discovery of Ignaz Semmelweis that hand washing could prevent disease in obstetric patients to the development of the first vaccine for small pox by Edward Jenner, historically; pediatric medicine has been at the forefront of medical innovations that have improved care for patients of all ages. Today, however, pediatric medicine is an area that is often forgotten by our generation of medical innovators. Advances in pediatric medicine frequently result in retrofitting adult solutions to these smaller patients. While this “bang to fit” model has led to some important improvements in pediatric care, such as gene therapies, there are other challenges in pediatric medicine that do not require the genius of the likes of Jenner or Semmelweis to address. We have the technologies and clinical evidence to save many lives by implementing practice changes to stop preventable deaths such as those due to failure to rescue and morbidities like retinopathy of prematurity. We can stop most, if not all of the 200,000 plus preventable deaths and the many more morbidities that occur each year in our hospitals with an “all-in” commitment by clinicians, patient advocates, hospitals, and medical technology companies to focus on seven major areas of change: breaking down information and communication silos between hospitals, med-tech companies, health IT and patients ; promoting transparency; creating safety solutions to the challenges that are causing preventable deaths ; using incentives and disincentives to reduce preventable deaths; eliminating misaligned incentives; creating the “Patient Data Super Highway” and lastly and perhaps most importantly, promoting love and dignity in patient care. Masimo, the company I founded some 24 years ago has been on a journey to develop technologies to improve patient care and stop preventable deaths. With the Patient Safety Movement we join with many other companies, health care providers, advocates and patients to push toward our shared goal of ZERO preventable deaths by 2020.