Pro-inflammatory Cytokines as Biomarkers of Obesity Complications in Egyptian Children

Enas Abdelhamid
22
Dec

Pro-inflammatory Cytokines as Biomarkers of Obesity Complications in Egyptian Children

Background/ Objectives: The rate of obesity is increasing throughout the world. Obesity in adults’ research is characterized by chronic inflammation, associated with type 2 Diabetes and cardiovascular risk. The degree to which these changes occur in childhood obesity is not fully defined. This study aimed to explore the relation between circulating levels of pro-inflammatory cytokines, and obesity. Patients and Methods: This cross sectional case control study was carried out in 50 randomly selected prepubertal overweight and obese children compared with fifty apparently healthy children of matched age and sex. Serum levels of transforming growth factor-ß1, interleukin-6, and haptoglobin were measured by ELISA methods. Results: ANOVA test followed by Post Hoc test revealed highly significant increase in the serum levels of the transforming growth factor-ß1, interleukin-6 and haptoglobin among obese children compared to overweight and healthy children respectively. The body weight, BMI and BMI z-score were significantly positively correlated with serum levels of the 3 pro-inflammatory cytokines. Serum levels of interleukin-6, and haptoglobin were found to be strong predictors of severe obesity by linear regression analysis. Conclusions: Obesity is associated with chronic low-grade inflammation. High levels of interleukin-6 and haptoglobin are considered to be early biomarkers of inflammation associated with severe obesity with subsequent cardiovascular and type 2 diabetes risk